NEW CC CARDIOCARE™ SUPPORTS THEIR HEART FROM THE START
Introducing new PURINA® PRO PLAN® VETERINARY DIETS CC CardioCare™. A life changing blend of nutrients with the power to support cardiac function
PURINA® PRO PLAN® VETERINARY DIETS CC CardioCare™ is a complete dietetic pet food for adult dogs containing an advanced blend of nutrients (Cardiac Nutritional Blend -CNB) proven to support hearts with compromised mitral valve function from an early stage.
- Medium-Chain Triglycerides (MCTs)oil as an alternative energy source for the myocytes
- Key amino acids (L-Lysine, Methionine) precursors of carnitine, a crucial transporter of fatty acids into the mitochondria
- Fish oil (Omega-3 fatty acids) to help support natural anti-inflammatory processes
- Vitamin E to help reduce oxidative stress
- Magnesium which binds ATP to deliver energy to the cardiac cells
- Taurine to help maintain heart contractile function
Heart murmurs are turbulences in the blood flow that create a distinguishable sound during the heart auscultation.
A heart murmur can be a common disturbance in young dogs, and although a murmur will often subside with age, they can also be an early sign of heart disease.
Diagnostic tests will usually be performed to confirm the murmur is cardiac in origin and to determine the nature of any underlying disease.
Depending on its nature, rate of progression, patient age and condition, heart disease might lead to heart failure1.
- It is characterised by a slowly progressive mitral valve degeneration associated with alterations in energy metabolism, oxidative stress, inflammation, and in more advanced stages, heart enlargement2.
- In the early stages, dogs show no outward signs of disease and usually present as clinically normal.
- Identifying dogs when they are in the early stages of MMVD may help prevent progression3.
1. Keene B, Atkins CE, et al. ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. J Vet Intern Med 2019;33:1127-1140.
2. Borgarelli M, Haggstrom J. Canine degenerative myxomatous mitral valve disease: Natural history, clinical presentation and therapy. Vet Clin North Am Small Anim Pract 2010;40: 651–663.
3. Li Q, Heaney A, et al. Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: a blinded randomized controlled study in 36 dogs. BMC Veterinary Research. 2019; 15:425.
PURINA® PRO PLAN®
VETERINARY DIETS CC CardioCare™
is supported by scientific research
Dietary intervention can help slow progression and heart enlargement in dogs within early stages of myxomatous mitral valve disease (MMVD). (Li et al., 2019)*.
- The study evaluated the clinical impact of a diet formulated with a cardiac nutritional blend (CPB) designed to address metabolic alterations, and progression of naturally occurring early preclinical stage of MMVD in dogs.
- Results showed that a blend of nutrients, designed to address metabolic changes associated with MMVD in dogs, was able to slow or reverse cardiac changes within early and preclinical stages of MMVD.
*Li Q, Heaney A, et al. Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: a blinded randomised controlled study in 36 dogs. BMC Veterinary Research. 2019; 15:425.
Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs (Li et al., 2015)*.
- The study characterised molecular and metabolic pathways that might play a role in the pathogenesis and progression of MMVD, by applying metabolomics and transcriptomics techniques.
- Results showed that dogs with MMVD presented altered energy metabolism in cardiac tissues, as well as an increase in markers of oxidative stress.
- Many of the observed disturbances may benefit from nutritional or medical management, but additional research is needed.
*Li Q, Heaney A, et al. Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs. OMICS A Journal of Integrative Biology. 2015; 19:8.
Serum untargeted metabolomic changes in response to diet intervention in dogs with preclinical myxomatous mitral valve disease (Li et al., 2020)*.
- The study evaluated a cardiac nutritional blend (CPB) of nutrients in a 6-month dietary intervention to investigate changes in the metabolism of certain components.
- Numerous metabolites were identified reflecting improved cardiac bioenergetics and fatty acid utilisation by cardiac mitochondria in dogs fed the CPB diet.
- Metabolomic markers also suggest improved cellular redox state and reduced inflammation in MMVD dogs fed the CPB diet.
*Li Q, Laflamme DP, Bauer JE (2020) Serum untargeted metabolomic changes in response to diet intervention in dogs with preclinical myxomatous mitral valve disease. PLoS ONE 15(6): e0234404.